Aloe vera from Asphodelaceae family has a large amount of potentially active compounds with anti-oxidant, antidiabetic, and antihyperlipidemic activities. The leaf consists of three layers i.e. gel, latex and rind. Inner layer contains water (99%), glucomannans, amino acids, lipids, sterols and vitamins.
Obesity is a chronic disease resulting from the excessive accumulation of body fat. It causes health damage in adults, adolescents and children, both in developed and in developing countries. It is associated with many health-related complications such as insulin resistance, Type-2 diabetes mellitus (T2DM), and other metabolic disorders. In obese individuals, the accumulation of more fat occurs in the adipose tissue and later stage fat deposition takes place other than non-adipose tissue (e.g., muscle and liver).Some researchers found that the body weight and insulin resistance in diabetic patients treated with \ aloe vera gel complex reduced.
According to the present study, the anti-obesity effects of Aloe vera gel in a diet-induced obesity rat model was investigated. Plasma and tissue parameters and adipose lipase activities were determined. The results showed that obese rats displayed dyslipidemia and stress oxidative with excessive adipose tissue lipids. Aloe vera gel administration prevented adipose tissue accumulation and corrected the dyslipidemia and oxidative stress. In conclusion, Aloe vera reduced fat accumulation via its protective role against obesity-related metabolic alterations and antioxidant effects.